Today, back to our workshop in Eckernfoerde, Northern Germany. Countess Wolffskeel presented her amazing therapeutic success with biestmilch in genetic diseases like Coffin Lawry syndrome. Her therapeutic rationale is based on the concept of cell milieu modulation and downregulation of the inflammatory pressure the body is embedded in. By cell milieu modulation it is thus possible to alter the patterns of gene expression, and thus compensate for gene defects by a stimulating or depressing milieu respectively.
Genetic defects are then no inescapable destiny and the DNA is no holy grail anymore. It is »only« an essential component of the loop: RNA, nucleus, cytoplasma and protein synthesis, intracellular signal transduction, cell membrane, cell membrane receptors and extracellular matrix - a tightly cross-linked system of interdependent elements.
And what makes me extraordinarily happy is that biestmilch’s thought
concept of mode of action is perfectly fitting the recently pulished
views on the new gene in one of the world’s most reputed science
journals NATURE. And if once an idea made its way into Nature, one
could assume that a paradigm change is imminent, at least one needs not to feel like an insulated heretic anymore, hopefully…!
Quotes from NATURE|Vol 441|25 May 2006
The idea of genes as beads on a DNA string is fast fading. Protein-coding sequences have no
clear
beginning or end and RNA is a key part of the information package.
Identical twins are not necessarily identical anymore. A longlasting
secret contradicting the established view on the genetic code is
finally soundly disclosed.
- The degree of compelxity we’ve seen was not anticipated.
- When we started the ENCODE project I had a different view of what a gene was.
- The picture the studies paint is one of mind-boggling complexity.
- We’ve come to the realization that the genome is full of overlapping transcripts.«
Does this sound like the old dogma of the genetic code conveying
information only in one direction, from the DNA to protein synthesis
machinery? No!
DNA develops into an integral part of the cell and
its milieu, intertwined into the circular world of feedback loops
structuring and organizing our body and regulating its dynamic
equilibrium.
May 24th, 2007 at 20:19
“genetics is the utmost” a friend of mine stated some years ago. he believed that all and everything was ruled by genes, and I think he still believes in it. But in fact the matter is much more complex, Godfather did not create or invent “the gene” that rules and decides and probably punishes, the gene is part of a complex game and the way to act is absolutely influenced by processes from outside. Thus genes do not govern they are part of the network.